In 1667, Captain John Underhill negotiated with the Matinecock Indians to purchase land for a settlement that he and his fellow colonists would call Buckram. The town name lasted for nearly 200 years, until in 1856 the name was changed to Locust Valley based on the number of locust trees located in the area.
On April 19, 1869, the Long Island Rail Road opened the extension of the Glen Cove line, via a single track to Locust Valley, making it the terminus of the line until the railroad was extended to its current terminus in Oyster Bay in 1889.
With the arrival of the Long Island Rail Road, a commercial center developed and thrived around the Locust Valley station and the nearby intersection of Forest Ave/Buckram Road and Birch Hill Road. As the North Shore of Long Island grew into the Gold Coast in the early 20th century, the commercial center grew to serve the great estates that were being established in the surrounding communities of Bayville, Centre Island, Lattingtown, Mill Neck, Matinecock, Muttontown and The Brookvilles.