Items in New York Heritage are organized into collections, which provide additional context for understanding their significance and meaning.

This collection contains images of artifacts and people related to the Dudley Observatory.
Elizabeth Blackwell (1821-1910) was the first woman in the world to graduate from medical school and become a physician. The collection includes images of Dr. Blackwell and her writings dating to the late 19th century
The Proceedings of the Rochester Academy of Science include original papers relating to the natural history of western New York State and biographical articles on the scientists who contributed to knowledge within this field. The abstracts of papers and posters presented at the annual Scientific Paper Session are included in issues as well. Topics range from the glaciology of the area, the water levels of Lake Ontario, to the flora of Bergen Swamp and Mendon Ponds Park. The Proceedings have been published on an irregular schedule since 1890.
Photographs, historical objects, memorabilia and ledgers from 1887 to the 1990s reflecting the history of Vassar Brothers Medical Center.