Items in New York Heritage are organized into collections, which provide additional context for understanding their significance and meaning.

Photographs relating to the history of Rochester General Hospital during the late 19th and early 20th centuries.
This collection contains artifacts relating to the history of the Dudley Observatory.
Elizabeth Blackwell (1821-1910) was the first woman in the world to graduate from medical school and become a physician. The collection includes images of Dr. Blackwell and her writings dating to the late 19th century
A collection of mineral samples, artifacts, and photographs relating to the history of mining in Essex County
Collection of photographs taken from 1957 through 1968 of various buildings and grounds of Willard Psychiatric Center. The black-and-white photographs contain detailed studies of various buildings of the hospital, many of which have been since torn down