Items in New York Heritage are organized into collections, which provide additional context for understanding their significance and meaning.

Niagara Falls has a history of enticing people to dare the rapids. These daredevils have crossed the Falls over tightropes, barrels, boats, and other contraptions. The Daredevils of Niagara collection includes photographs, advertisements, articles, and other documents about the people who performed these stunts.
This collection contains several artifacts from the Robert L. Brown History of Medicine Collection, University at Buffalo, that highlight the life of Dr. Austin Flint. A renowned physician, Flint was one of the founding members of the University at Buffalo Medical School. As the most distinguished member of the founding faculty, he was named Professor of Principles and Practice of Medicine and Clinical Medicine, and he served as the first registrar and treasurer. In addition to his work at the medical school, he authored more than 200 articles and 16 books. Many of his articles were published in the "Buffalo Medical Journal", a journal that he himself founded.
The Dunham Family History collection contains portraits, photographs, and various documents saved by the Dunham family.