Items in New York Heritage are organized into collections, which provide additional context for understanding their significance and meaning.

Photographs, correspondence, and newspaper clippings relating to the early campuses of the Syracuse University College of Medicine in Syracuse, New York in the late 19th and early 20th century.
The Proceedings of the Rochester Academy of Science include original papers relating to the natural history of western New York State and biographical articles on the scientists who contributed to knowledge within this field. The abstracts of papers and posters presented at the annual Scientific Paper Session are included in issues as well. Topics range from the glaciology of the area, the water levels of Lake Ontario, to the flora of Bergen Swamp and Mendon Ponds Park. The Proceedings have been published on an irregular schedule since 1890.
The Rochester General Hospital School of Nursing was one of the earliest nursing schools in the United States. This collection includes class photographs and portraits of the graduates, spanning the School’s inception in the late-19th century  through its closure in the mid-20th century.
Rochester Homeopathic Hospital, later known as Genesee Hospital, was an important medical facility in the Rochester region. This collection includes images of the Hospital throughout its existence.
This collection contains materials related to the San Luis project.

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