Items in New York Heritage are organized into collections, which provide additional context for understanding their significance and meaning.

Photographs, correspondence, and newspaper clippings relating to the early campuses of the Syracuse University College of Medicine in Syracuse, New York in the late 19th and early 20th century.
A collection of mineral samples, artifacts, and photographs relating to the history of mining in Essex County
Samples of advertisements and packaging used by Dr. R.V. Pierce to market his products in the late 19th and early 20th centuries.
Rochester Homeopathic Hospital, later known as Genesee Hospital, was an important medical facility in the Rochester region. This collection includes images of the Hospital throughout its existence.
Photographs and documents relating to the Syracuse Free Dispensary which operated from 1888-1964.

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