Items in New York Heritage are organized into collections, which provide additional context for understanding their significance and meaning.

This collection consists of letters and marginalia of Samuel Clemens, artifacts associated with him and photos having to do with Clemens' time in Elmira and the family and friends that comprised his circle.
A collection of mineral samples, artifacts, and photographs relating to the history of mining in Essex County
Photographs, correspondence, and newspaper clippings relating to the early campuses of the Syracuse University College of Medicine in Syracuse, New York in the late 19th and early 20th century.
Photographs, correspondence, textiles, and other items pertaining to the family of Mary Ann Thorne Chadeayne.
Historical artifacts including clothing, tools, and medical equipment.

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